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New Drug Against Skin Cancer

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To prevent skin cancer is the best precaution against the sun’s rays. <br />
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Now, this prevention with medical and pharmacological advances could bring an end to skincancer. <br />
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The U.S. Food and Drug Administration (FDA for its acronym in English) has just approved a new drug that has shown to prolong the lives of people with advanced melanoma. </div>
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It is called , <b>ipilimumab</b>.<br />
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People who have some type of melanoma are in luck.</div>
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So far the only treatment before the disease was chemotherapy, which also does not stop the cancer and in 20 percent of cases. <br />
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Now, thanks to pharmaceutical research, there is another less invasive treatment, the Yervoy (trade name ipilimumab).<br />
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As explained by the director of the office assessment of the FDA anti-cancer treatments, Richard Pazdur, although there are many treatments in the process of investigation, “it is the first therapy approved by the FDA which clearly shows that longer life of people with advancedmelanoma. “<br />
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And in the clinical study conducted with 649 patients, there was actually to increase the survival of them in about 10 months.<br />
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Why is effective against skin cancer?<br />
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But how exactly to be as effective? </b><br />
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The drug essentially stops the action of a protein active in melanoma, the CTLA-4, which disrupts the immune system and prevents the body fight the cancer. <br />
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In this way, makes the body react to the melanoma extending the life of patients.<br />
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In any case, the FDA has advised to study each case individually in order to avoid toxic reactions.<br />
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In Spain and administering this drug in certain cases (people with distant and unresponsive to chemotherapy). <br />
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However, this approval could lead to general approval in our country, allowing this drug without the red tape that must be passed today.<br />
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According to the World Health Organization, skin cancer causes 66,000 deaths worldwide each year.</div>
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New Drug Against Skin Cancer

To prevent skin cancer is the best precaution against the sun’s rays. Now, this prevention with medical and pharmacological advances co...

Vitamin D would be essential to prevent colon cancer

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New studies by researchers from the Howard Hughes Medical Institute indicate that vitamin D protects against colon cancer because it helps in the detoxification of chemicals that trigger cancer and that are released during digestion of high fat foods.<br />
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The discovery, which was conducted by a research team that included researchers from the Howard Hughes Medical Institute David J. Mangelsdorf, Medical Center of Texas Southwestern University, and Ronald M. Evans of the Salk Institute and colleagues at the University of Arizona, was published in the issue of May 17, 2002, issue of Science.<br />
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"Our results suggest a new way of looking at the relationship between nutrition and cancer, particularly on how vitamin D protects us from colon cancer."<br />
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<b>David J. Mangelsdorf</b><br />
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Studies show that a specific type of bile acid called lithocholic acid (CLA), a known carcinogen, activates the receptor for vitamin D.<br />
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When you activate the vitamin D receptor, this in turn activates other proteins that bile acid detoxification.<br />
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Research suggests that a drug that acts like vitamin D might help prevent colon cancer by activating the vitamin D receptor and eliminate body ALC. One obstacle to be overcome, however, is that high intake of vitamin D or drugs that mimic the activity of vitamin D can lead to dangerous blood levels of calcium.<br />
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The colon cancer expert, Bert Vogelstein, an HHMI investigator at the Sidney Kimmel Cancer Center comprenhensive Johns Hopkins University said: "These studies provide important new clues about the relationship between vitamin D, bile acids and colorectal cancer and have significant implications for the prevention of colorectal cancer in the future. "<br />
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Mangelsdorf, Evans and colleagues studied the effects of bile acid, LCA, which is produced as a byproduct when intestinal bacteria digest the primary bile acids are produced in the liver. </div>
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Primary bile acids help the body digest fats in the diet. The experiments showed that CLA activates the vitamin D receptor, which then activates additional genes that help detoxify the FTA.<br />
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"There is a lot of epidemiological data and certain scientific data, which were to suggest a correlation between diets high grade tenor, bile acids, such as the FTA, and colon cancer," said Mangelsdorf.<br />
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"But there have been causal links, it has been frustrating trying to understand the relationship between our Western-style diet rich in fat and colon cancer."<br />
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Although it was shown that vitamin D could prevent colon cancer in rats treated with LAC, and that human beings signaling pathways defective vitamin D have a higher incidence of colon cancer, it remained unclear how vitamin D prevented colon cancer. A reasonable theory, according to Mangelsdorf, was that vitamin D and CLA triggered a biochemical pathway involved in the detoxification of the FTA. The best candidate was a way to involve the receptor for vitamin D.<br />
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In a series of studies, researchers showed that the vitamin D receptor binds tightly to the FTA.<br />
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But the researchers also needed to demonstrate that ALC binding actually activates a key gene, called CYP3A, which activates the detoxification machinery of the cell.<br />
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The scientists attached a "reporter" gene CYP3A in cultured human cells, to detect whether the CYP3A gene was activated when the ALC joined the vitamin D receptor<br />
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"Other investigators had published data showing that vitamin D could activate this gene, but it was a great surprise that the FTA could also do it," said Mangelsdorf. The scientists also conducted experiments on mice, which found that feeding CLA to animals produced the activation of certain genes that are targets of vitamin D receptor<br />
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The scientists showed, ultimately, that the vitamin D receptor was the only receptor activated by the FTA. "We showed that in our knock-out mice, CLA can still induce the expression of CYP3A, like vitamin D," said Mangelsdorf. "So this crucial experiment showed that vitamin D and CLA did not work through another receptor, but did so through the vitamin D receptor."<br />
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According to Mangelsdorf, the results suggest that vitamin D receptor acts as a sensor for toxic chemical LAC. Other receptors in the body can detect fat from the diet and other foreign chemicals, and can serve to "alert" the body to begin detoxification when the chemicals reach dangerous levels.<br />
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"Our results suggest a new way of looking at the relationship between nutrition and cancer, particularly on how vitamin D protects us from colon cancer," he said. "One problem with the use of vitamin D as a protective drug, has always been that it causes hypercalcemia. </div>
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But now we know that there is another endogenous compound, the FTA, which can also bind to the receptor, we can develop protective drugs that do not cause hypercalcemia, but to activate the detoxification pathway. "</div>
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Vitamin D would be essential to prevent colon cancer

New studies by researchers from the Howard Hughes Medical Institute indicate that vitamin D protects against colon cancer because it help...

Intravenous Vitamin C for Cancer Cure

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Science and medicine have made great progress in research for cancer treatments, and it is important to keep abreast of these new findings, cancer has many variants, fortunately each has its own specialized studies, see in this section that says about intravenous vitamin C.<br />
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Intravenous Vitamin C for Cancer Cure

Science and medicine have made great progress in research for cancer treatments, and it is important to keep abreast of these new finding...

Scientists re-write rulebook on breast cancer in landmark global study

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Scientists at the BC Cancer Agency and University of British Columbia have identified new breast cancer genes that could change the way the disease is diagnosed and form the basis of next generation treatments.</div>
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Researchers have reclassified the disease into 10 completely new categories based on the genetic fingerprint of a tumour. </div>
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Many of these genes could offer much needed insight into breast cancer biology, allowing doctors to predict whether a tumour will respond to a particular treatment. </div>
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Whether the tumour is likely to spread to other parts of the body or if it is likely to return following treatment.</div>
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The study, published online today in the international journal Nature, is the largest global study of breast cancer tissue ever performed and the culmination of decades of research into the disease.</div>
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In the future, this information could be used by doctors to better tailor treatment to the individual patient.</div>
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The team at the BC Cancer Agency, in collaboration with Cancer Research UK’s Cambridge Research Institute and Manitoba Institute of Cell Biology at University of Manitoba, analyzed the DNA and RNA of 2,000 tumour samples taken from women diagnosed with breast cancer between five and 10 years ago. </div>
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The sheer number of tumours mapped allowed researchers to spot new patterns in the data.</div>
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Study milestones include :</div>
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Classified breast cancer into 10 subtypes grouped by common genetic features, which correlate with survival. </div>
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This new classification could change the way drugs are tailored to treat women with breast cancer.</div>
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Discovered several completely new genes that had never before been linked to breast cancer. </div>
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These genes that drive the disease are all targets for new drugs that may be developed. </div>
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This information will be available to scientists worldwide to boost drug discovery and development.</div>
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Revealed the relationship between these genes and known cell signaling pathways networks that control cell growth and division. </div>
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This could pinpoint how these gene faults cause cancer, by disrupting important cell processes.</div>
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This is the second major breakthrough announced by BC Cancer Agency scientists in as many weeks. </div>
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The decoding of the genetic makeup of the most deadly of breast cancers is here, triple-negative breast cancer, which until then was defined by what it was missing, not what it was. </div>
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Similar to that announcement, today’s new discovery identifies genes that were previously unknown to be linked to breast cancer and makes it clear that breast cancer is an umbrella term for what really is a number of unique diseases.</div>
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While the research is unlikely to benefit women who currently have breast cancer, it substantially advances how scientists approach further research and clinical trials by providing them with a springboard to develop new treatment options and drugs targeted to specific genes.</div>
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<b>The research was carried out in collaboration with the following institutes :</b></div>
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British Columbia Cancer Agency, Vancouver</div>
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University of British Columbia, Vancouver</div>
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Department of Oncology, University of Cambridge</div>
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Department of Applied Mathematics and Theoretical Physics, University of Cambridge</div>
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Department of Genetics, The Institute for Cancer Research</div>
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Oslo University Hospital</div>
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Department of Histopathology, University of Nottingham</div>
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Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre</div>
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King’s College London, Breakthrough Breast Cancer Research Unit</div>
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Manitoba Institute of Cell Biology, University of Manitoba</div>
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NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London</div>
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Institute for Clinical Medicine, Faculty of Medicine, University of Oslo</div>
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Cambridge Experimental Cancer Medicine Centre.</div>
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The research was generously supported by the BC Cancer Foundation, Canadian Breast Cancer Foundation - BC/Yukon Region and Prairies/NWT Region, Michael Smith Foundation and Cancer Research UK.</div>
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The BC Cancer Agency, an agency of the Provincial Health Services Authority, is committed to reducing the incidence of cancer, reducing the mortality from cancer, and improving the quality of life of those living with cancer. It provides a comprehensive cancer control program for the people of British Columbia by working with community partners to deliver a range of oncology services, including prevention, early detection, diagnosis and treatment, research, education, supportive care, rehabilitation and palliative care. </div>
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Cancer Research UK is the world’s leading cancer charity dedicated to saving lives through research. </div>
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The charity’s groundbreaking work into the prevention, diagnosis and treatment of cancer has helped save millions of lives. </div>
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This work is funded entirely by the public. </div>
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Cancer Research UK has been at the heart of the progress that has already seen survival rates in the UK double in the last forty years. </div>
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Cancer Research UK supports research into all aspects of cancer through the work of over 4,000 scientists, doctors and nurses. </div>
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Together with its partners and supporters, Cancer Research UK's vision is to beat cancer.</div>

Scientists re-write rulebook on breast cancer in landmark global study

Scientists at the BC Cancer Agency and University of British Columbia have identified new breast cancer genes that could change the way ...

Drug boost effectiveness of cancer vaccine

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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhWYKouyvcWhQMZ3yKT3hnGsv9HfVSEnexmE1pAPgfu264kvRwV7T_Nu4OgxOfZL6Bx0Y9Dr4ISMIEgrK-2CWVcuvtuuynU6jz5YF9mjEpigNA4LcYz92VMkI5TVfqsOvX2u3Q8nWgvdtc/s1600/Zenapax+cancer+ending.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="154" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhWYKouyvcWhQMZ3yKT3hnGsv9HfVSEnexmE1pAPgfu264kvRwV7T_Nu4OgxOfZL6Bx0Y9Dr4ISMIEgrK-2CWVcuvtuuynU6jz5YF9mjEpigNA4LcYz92VMkI5TVfqsOvX2u3Q8nWgvdtc/s200/Zenapax+cancer+ending.jpg" width="200" /></a></div>
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Dr. Robert H. Vonderheide, MD, PhD (Damon Runyon-Lilly Clinical
Investigator ) and colleagues at University of Pennsylvania School of Medicine,
Philadelphia, reported that the drug daclizumab (Zenapax) improved the survival
of breast cancer patients taking a cancer vaccine by 30 percent (seven months).</div>
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<span lang="es">Compared to those patients not taking the drug.  <o:p></o:p></span></div>
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<span lang="es">Daclizumab, approved for use in preventing transplant rejection, targets
Tregs (regulatory T cells) that normally prevent the immune system from
detecting and attacking tumors.  <o:p></o:p></span></div>
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<span lang="es">The researchers tested the drug in ten patients with metastatic breast
cancer prior to giving them an experimental breast cancer vaccine.  <o:p></o:p></span></div>
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<span lang="es">The tumors stopped growing in six of these patients.  <o:p></o:p></span></div>
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<span lang="es">This drug, in combination with other immunotherapy, may be useful for
treatment of other cancer types as well. 
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<span lang="es">These promising results were published in the journal Science
Translational Medicine.<o:p></o:p></span></div>

Drug boost effectiveness of cancer vaccine

Dr. Robert H. Vonderheide, MD, PhD (Damon Runyon-Lilly Clinical Investigator ) and colleagues at University of Pennsylvania School of Me...