Cancer Ending

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Small particles loaded with medicine could be a future weapon for cancer
treatment.</div>
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<span lang="es">A recently published study shows how nanoparticles can be formed to
efficiently carry cancer drugs to tumor cells. <o:p></o:p></span></div>
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<span lang="es">And because the particles can be seen in Mri images, they are traceable.<o:p></o:p></span></div>
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<span lang="es">Both therapeutic and diagnostic in function, the so-called "theranostic"
particles were developed by a team including Kth Professor Eva
Malmström-Jonsson, from the school of Chemical Science, as well as researchers
at sweden's Chalmer's University and the Karolinska Institute in Stockholm.<o:p></o:p></span></div>
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<span lang="es">Malmström-Jonsson says that the particles, which the team developed for
breast cancer treatment, are biodegradable and non-toxic. <o:p></o:p></span></div>
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<span lang="es">Their research was published in the science journal Particle &
Particle Systems Characterization.<o:p></o:p></span></div>
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<span lang="es">The study resulted in a method to make nanoparticles spontaneously build
themselves up with tailored macromolecules. <o:p></o:p></span></div>
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<span lang="es">The formation requires a balance between the particle's hydrophilic
(capable of dissolving in water) and hydrophobic (not dissolvable in water)
parts. <o:p></o:p></span></div>
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<span lang="es">The hydrophobic portion makes it possible to fill the particle with the
drug.<o:p></o:p></span></div>
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<span lang="es">A relatively high concentration of the natural isotope 19F (fluorine)
makes the particles clearly visible on high-resolution images taken by MRI
(magnetic resonance imaging). <o:p></o:p></span></div>
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<span lang="es">By following the path of theranostic nanoparticles in the body, it is
possible to obtain information about how the drug is taken up by the tumor and
whether the treatment is working.<o:p></o:p></span></div>
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<span lang="es">Scientists filled nanoparticles with the chemotherapy drug doxorubicin
(known as chemo), which is used today to treat bladder, lung, ovarian and
breast cancer, In experiments on cultured cells, they showed that the particles
themselves are not harmful but can effectively kill cancer cells after being
loaded with the drug.<o:p></o:p></span></div>
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<span lang="es">The next step is to develop the system to target tumors that are
difficult to treat with chemotherapy, such as brain tumors, pancreatic cancer,
and drug-resistant breast cancer tumors.<o:p></o:p></span></div>
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<span lang="es">"By targeting groups on the surface, or by changing the size or
introducing ionic groups on our nanoparticles, one can increase the selective
uptake in these tumors," says Andreas Nystrom, an associate professor of
nanomedicine at the Swedish Medical Nanoscience Center and Department of
Neuroscience, Karolinska Institute.<o:p></o:p></span></div>
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<span lang="es">In the long term, research can result in tailored chemotherapy
treatments that seek out tumor cells. <o:p></o:p></span></div>
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<span lang="es">This would enable the toxic drug to be delivered more specifically to
the tumor, making the treatment more effective while reducing side effects.<o:p></o:p></span></div>
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<span lang="es">"What we want to do is try to give nanoparticles a homing function
on the surface so that the drug is as effective as possible and can be
transported to the right place," Malmström-Jonsson says.<o:p></o:p></span></div>
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<span lang="es">The study is funded in part by two grants from the Swedish Research
Council to Andreas Nystrom and Eva Malmström-Jonsson. <o:p></o:p></span></div>
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<span lang="es">Malmström-Jonsson and Nystrom are also active in the company Polymer
Factory Sweden AB.<o:p></o:p></span></div>

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